PPM1E Polyclonal Antibody, 50ul Plates & Dishes The autosomal dominant cerebellar ataxias

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum

and the regulation of cell growth

The MAGED genes are clustered on chromosome Xp11

originally described in yeast as cell division cycle regulatory proteins

This receptor is expressed in neurons in the limbic regions of the brain

PPM1E Polyclonal Antibody, 50ul Plates & Dishes The autosomal dominant cerebellar ataxiasThis gene encodes a member of the PPM family of serine threonine protein phosphatases. The encoded protein is localized to the nucleus and dephosphorylates and inactivates multiple substrates including serine threonine protein kinase PAK 1, 5' AMP activated protein kinase (AMPK) and the multifunctional calcium calmodulin dependent protein kinases. Alternatively spliced transcript variants have been observed for this gene.