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These drugs do have a lot of similarities but also important differences

doi:10.1016/j.crohns.2013.01.009 8Kane S, Khatibi B, Reddy D

This triple mechanism of action distinguishes retatrutide from existing approved therapies such as semaglutide (a GLP-1 receptor agonist) or tirzepatide (a dual GIP/GLP-1 agonist)