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2 Inhibition of tumor cell proliferation in response to PA Cell proliferation is a critical process in cell growth and differentiation (23).Abnormal cell proliferation is a key characteristic of cancer (24), making the inhibition of tumor cell proliferation a crucial strategy in cancer therapy (25).Notably, both in vitro and in vivo studies have demonstrated the potential of PA in effectively inhibiting the proliferation of various cancer cell types, including prostate cancer, gastric cancer, and breast cancer cells

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The ratio of M1 to M2 phenotypes Compared with M2 cells, activated M1 macrophages are less sensitive to drug-induced ferroptosis, a difference that has been shown to depend on the production of nitric oxide (NO)

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