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GLP-1 receptor activated insulin secretion from pancreatic -cells: mechanism and glucose dependence

Cancer outcomes are frequently reported as secondary or exploratory endpoints, with inconsistent methods of diagnosis and follow-up (Gerstein et al., 2019

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A phase 2 trial of semaglutide 2.4 mg in 71 cirrhotic patients confirmed an acceptable safety profile without significant decompensation events, although the primary histological endpoint was not met, possibly due to the limited ability of antifibrotic remodeling to achieve biopsy-detectable fibrosis stage improvement in established cirrhosis over 48 weeks [46]

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