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Disclosure The author declares that they do not have any financial involvement or affiliations with any organisation, association or entity directly or indirectly related to the subject matter or materials presented in this narrative review

The distinct pathophysiological traits of these stagessuch as amyloid aggregation, abnormal accumulation of tau protein, neuroinflammation, and oxidative stressare examined for their impact on therapy

It also has limited safety research specific to children's skin

The comet parameters of antioxidant groups (P 37.5 , P 75 , P 150 , P 300 groups) were significantly increased comet parameters depend on pycnogenol doses compared with to control group

For analysis, the arena was divided into a peripheral zone measuring 8 cm from the edge of the arena walls, and a central zone around 40% of the total surface of the arena