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Statistical significance was assessed using a correlated-samples two-way ANOVA followed by Sidaks multiple comparisons adjustment ( a ), two-way ANOVA ( i ) followed by Tukeys multiple comparison adjustment ( b ), KruskalWallis tests followed by Dunns multiple comparisons adjustment ( c (Y1.7), j ), one-way ANOVA followed by Tukeys multiple comparisons adjustment ( c (Y3.3)), or nparLD tests ( d h )